[Class 2 drug] Mitsubishi Tanabe Pharma Cerequinone S (Can only be used by those diagnosed with irritable bowel syndrome) 20 tablets

Relief of the following symptoms of irritable bowel syndrome: Repeated or alternating diarrhea and constipation accompanied by abdominal pain or discomfort (limited to those who have previously been diagnosed and treated by a doctor).

Please take the following amount before or after meals with water or hot water without chewing. Age Single dose Number of doses Adults (15 years and older) 1 tablet 3 times a day Do not take if under 15 years old

Ingredients (daily dose: 3 tablets) Ingredient content Trimebutine maleate 300mg Additives: Ethylcellulose, carmellose Ca, Mg stearate, cellulose, hypromellose, macrogol

■What not to do (If you do not follow these guidelines, your current symptoms may worsen or side effects may occur more easily.) 1. Do not take this medicine for the following people: (1) Persons who have not received a diagnosis or treatment for irritable bowel syndrome from a doctor. (2) People who are not sure whether their irritable bowel syndrome has recurred (for example, the symptoms this time are different from when they were previously diagnosed and treated for irritable bowel syndrome). (3) People who feel the need to go to the toilet to defecate or have abdominal pain even during the night, such as while sleeping. (4) People who have a fever. (5) People with joint pain. (6) People with mucus and bloody stool (melena). (7) People who have recurring severe diarrhea. (8) People who have acute severe diarrhea. (9) People who have abdominal pain that does not improve with defecation. (10) People who have vomiting. (11) Persons who have unexpectedly lost 3 kg or more in weight within 6 months. (12) Persons with a history of colon cancer or inflammatory bowel disease (Crohn's disease, ulcerative colitis, etc.). (13) Persons who have had allergic symptoms due to this drug or its ingredients. (14) Children under 15 years old. 2. Please do not use it for a long period of time. ■To consult 1. The following people should consult a doctor, pharmacist, or registered salesperson before taking this medicine. (1) Persons receiving treatment from a doctor. (2) Pregnant women or people who appear to be pregnant. (3) People who are breastfeeding. (4) People over 50 years old. (5) People with anemia. (6) People who have had allergic symptoms due to medicines, etc. (7) Persons who have received the following diagnosis. Liver disease, diabetes, thyroid dysfunction, hyperparathyroidism (8) People with a family history of colorectal cancer or inflammatory bowel disease. (9) People who have severe abdominal pain or constipation. 2. If the following symptoms appear after taking this medicine, it may be a side effect, so stop taking it immediately and consult your doctor, pharmacist, or registered salesperson with this package insert. [Related area: Symptoms] Skin: rash, itching, hives Gastrointestinal: Constipation, diarrhea, stomach rumbling, dry mouth, numbness in the mouth, nausea, vomiting Neuropsychiatric system: drowsiness, dizziness, fatigue, headache Others: palpitations, difficulty urinating, urinary retention In rare cases, the following serious symptoms may occur. In that case, please see a doctor immediately. [Symptom name: Symptom] Liver dysfunction: Fever, itching, rash, jaundice (yellowing of the skin and whites of the eyes), brown urine, general malaise, loss of appetite, etc. may occur. 3. If your symptoms do not improve even after taking the medicine for one week, or if you take the medicine for more than two weeks even if your symptoms improve, please consult your doctor, pharmacist, or registered salesperson with this package insert. However, if you plan to take it for more than 2 weeks, please limit it to a maximum of 4 weeks.

(1) Store in a cool, dry place away from direct sunlight. (2) Please keep out of reach of children. (3) Do not transfer to another container. (It may cause misuse or change in quality.) (4) Do not take products that have passed their expiration date.