EVE pain relief medicine is a series first introduced by the Japanese pharmaceutical giant SS Pharmaceuticals Co., Ltd in 1985. With added potent anti-inflammatory ingredient Ibuprofen, the EVE series has become the first choice for many to alleviate menstrual pain, headaches, fever, and other symptoms. Known for its high efficacy, the EVE series holds a significant share in Japan's over-the-counter market.
※ EVE pain relief medicine can also be used for headaches and fever symptoms after COVID-19 vaccination.

Newly Released in September 2024 - EVE THREE SHOT Premium

In September 2024, after a 7-year hiatus, Japan's EVE pain relief medicine introduces a new series - EVE THREE SHOT Premium. Unlike other EVE pain relief medicines, this series includes 2 analgesic and antipyretic ingredients (Ibuprofen + Acetaminophen), making it the highest specification pain relief medicine in the EVE series. See the new series immediately

This article will comprehensively analyze the EVE pain relief medicine series by comparing its ingredients, indications, side effects, prices, etc., to help you easily choose the right EVE pain relief medicine for yourself!

Table of Contents

• Main Ingredients and Effects of EVE Pain Relief Medicine
• Comparison Table of All EVE Pain Relief Medicine Ingredients
• How to Choose EVE Pain Relief Medicine? Detailed Description of All Series
  • EVE THREE SHOT Premium【New Release in September 2024】
  • EVE Quick DX Gold Box
  • EVE Quick Silver Box
  • EVE A Tablets EX Pink Box
  • EVE A Tablets White Box
• Common Questions about EVE Pain Relief Medicine
• Side Effects and Precautions for EVE Pain Relief Medicine
• Overview of Products Introduced in This Article

Main Ingredients and Effects of EVE Pain Relief Medicine

Ibuprofen (イブプロフェン)

A non-steroidal anti-inflammatory drug. It inhibits the production of prostaglandins (sources of pain), providing antipyretic and analgesic effects. However, such medicines may have gastrointestinal side effects, so individuals with gastrointestinal issues or those using the medication to treat stomach pain should be particularly cautious.

Acetaminophen (アセトアミノフェン)

A central analgesic. It reduces the sensation of pain by inhibiting the transmission of pain signals in the brain's central nervous system, offering both analgesic and antipyretic effects. This ingredient is found in many fever reducers like Tylenol, as well as in general cold medications and liquid cold remedies. Care should be taken to avoid excessive intake to prevent an added burden on the kidneys.

Allyl Isopropyl Acetylurea (アリルイソプロピルアセチル尿素)

Suppresses cerebral blood vessel dilation and enhances the analgesic effect of Ibuprofen. As a sedative ingredient, it may cause drowsiness. Therefore, do not drive or operate machinery after taking this medicine. Also, avoid drinking alcohol before and after taking it.

Magnesium Oxide (酸化マグネシウム)

Protects the stomach lining.

Anhydrous Caffeine (無水カフェイン)

Suppresses cerebral blood vessel dilation, assisting the analgesic effect of Ibuprofen.

Comparison Table of All EVE Pain Relief Medicine Ingredients

Below are the main ingredients and their amounts (per dose) for each series of EVE pain relief medicine.

Item	EVE A Tablets	EVE A Tablets EX	EVE Quick	EVE Quick DX	EVE THREE SHOT Premium
Ibuprofen	150mg	200mg	150mg	200mg	195mg
Acetaminophen	×	×	×	×	195mg
Allyl Isopropyl Acetylurea	60mg	60mg	60mg	60mg	× non-drowsy
Magnesium Oxide	×	×	100mg	100mg	70mg
Anhydrous Caffeine	80mg	80mg	80mg	80mg	65mg

How to Choose EVE Pain Relief Medicine? Detailed Explanation of the Full Series

EVE THREE SHOT Premium Triple Effective Pain Relief Medicine [Coming September 2024]

Product Features:

☑️ Contains no drowsy ingredients
☑️ Rapid and effective relief for "headaches, menstrual pain, shoulder and back pain"
☑️ Combines two analgesic and antipyretic ingredients: Ibuprofen and Acetaminophen
☑️ Contains stomach-protecting ingredients (antacid) for pain and fever relief, headache medicine

Product Profile:

• Japanese Product Name: イブスリーショットプレミアム
• Classification: Class ② OTC drug
• Dosage Form: Tablet
• Indications: Headache, menstrual pain, shoulder pain, toothache, sore throat, joint pain, muscle pain, neuralgia, back pain, post-extraction pain, contusion pain, ear pain, fracture pain, sprain-related pain, trauma pain relief, fever chill relief, fever reduction
• Dosage and Administration: Adults (15 years and older) / take 3 tablets per dose
• Main Ingredients: Ibuprofen, Acetaminophen, Magnesium Oxide, Anhydrous Caffeine
• Drowsy Ingredients: None
• Antacid: Yes
• Dokodemo Price: 60 tablets / 2,486 JPY

EVE Quick DX Pain Relief Medicine Gold Box

Product Features:

☑️ Highest Ibuprofen content in the series at 200mg
☑️ Exclusive formulation for faster dissolution and absorption of Ibuprofen
☑️ Contains stomach-protecting ingredients (antacid) for pain and fever relief, headache medicine

Product Profile:

• Japanese Product Name: イブクイック頭痛薬DX
• Classification: Class ② OTC drug
• Dosage Form: Tablet
• Indications: Headache, shoulder pain, toothache, menstrual pain, sore throat, joint pain, muscle pain, neuralgia, back pain, post-extraction pain, contusion pain, ear pain, fracture pain, sprain-related pain, trauma pain relief, fever chill relief, fever reduction
• Dosage and Administration: Adults (15 years and older) / take 2 tablets per dose
• Main Ingredients: Ibuprofen, Isopropylantipyrine, Magnesium Oxide, Anhydrous Caffeine
• Drowsy Ingredients: Yes
• Antacid: Yes
• Dokodemo Price: 60 tablets / 1,700 JPY

EVE Quick Pain Relief Medicine Silver Box

Product Features:

☑️Exclusive formulation for faster dissolution and absorption of Ibuprofen
☑️Contains stomach-protecting ingredients (antacid) for pain and fever relief, headache medicine

Product Profile:

• Japanese Product Name: イブクイック頭痛薬
• Classification: Class ② OTC drug
• Dosage Form: Tablet
• Indications: Headache, shoulder pain, toothache, menstrual pain, sore throat, joint pain, muscle pain, neuralgia, back pain, post-extraction pain, contusion pain, ear pain, fracture pain, sprain-related pain, trauma pain relief, fever chill relief, fever reduction
• Dosage and Administration: Adults (15 years and older) / take 2 tablets per dose
• Main Ingredients: Ibuprofen, Isopropylantipyrine, Magnesium Oxide, Anhydrous Caffeine
• Drowsy Ingredients: Yes
• Antacid: Yes
• Dokodemo Price: 60 tablets / 1,798 JPY

EVE A Tablets EX Pain Relief Medicine Pink Box

Product Features:

☑️ Highest Ibuprofen content in the series at 200mg
☑️ Suitable for those suffering from menstrual pain
☑️ Smaller diameter suitable for those who have trouble swallowing large pills
☑️ Does not contain stomach-protecting antacids

Product Profile:

• Japanese Product Name: イブA錠EX
• Classification: Class ② OTC drug
• Dosage Form: Tablet
• Indications: Menstrual pain, headache, toothache, sore throat, joint pain, muscle pain, neuralgia, back pain, shoulder stiffness, post-extraction pain, contusion pain, ear pain, fracture pain, sprain-related pain, trauma pain relief, fever chill relief, fever reduction
• Dosage and Administration: Adults (15 years and older) / take 2 tablets per dose
• Main Ingredients: Ibuprofen, Isopropylantipyrine, Anhydrous Caffeine
• Drowsy Ingredients: Yes
• Antacid: No
• Dokodemo Price: 40 tablets / 830 JPY

EVE A Tablets Pain Relief Medicine White Box

Product Features:

☑️ Smaller diameter suitable for those who have trouble swallowing large pills
☑️ Suitable for those seeking cost-effectiveness over immediate effect
☑️ Does not contain stomach-protecting antacids

Product Profile:

• Japanese Product Name: イブA錠
• Classification: Class ② OTC drug
• Dosage Form: Tablet
• Indications: Menstrual pain, headache, toothache, sore throat, joint pain, muscle pain, neuralgia, back pain, shoulder stiffness, post-extraction pain, contusion pain, ear pain, fracture pain, sprain-related pain, trauma pain relief, fever chill relief, fever reduction
• Dosage and Administration: Adults (15 years and older) / take 2 tablets per dose
• Main Ingredients: Ibuprofen, Isopropylantipyrine, Anhydrous Caffeine
• Drowsy Ingredients: Yes
• Antacid: No
• Dokodemo Price: 60 tablets / 865 JPY

Frequently Asked Questions about EVE Pain Relief Medicine

Can I take it with drinks other than water, like tea or coffee?

Please take it with water or warm water.

When is the best time to take it after pain starts? Is it better to take it after meals?

It's most effective when taken as soon as the pain begins, but it's advisable to have a small amount of food first to avoid taking it on an empty stomach.

What should I do if the pain doesn't subside an hour after taking the medicine? Can I take an additional dose?

EVE A Tablets and EVE Quick can be taken up to 3 times a day with at least 4 hours in between doses. EVE A Tablets EX, EVE Quick DX, and EVE THREE SHOT Premium can be taken up to 2 times a day with at least 6 hours in between doses. If experiencing unprecedented pain, it is advisable to consult a physician.

Can children under 15 years old take this medicine?
The entire EVE series is currently suitable only for individuals aged 15 and above.

Is it effective for other types of pain besides headaches?

Yes, it is effective for headaches, back pain, shoulder pain, sore throat, and menstrual pain.

Can it be used long-term?

Long-term use is not recommended. If symptoms do not improve after 5-6 doses of EVE A Tablets or EVE Quick, or 3-4 doses of EVE A Tablets EX, EVE Quick DX, or EVE THREE SHOT Premium, please consult a physician.

Does it contain acetylsalicylic acid?

No, EVE products do not contain acetylsalicylic acid.

Does it contain ingredients that cause drowsiness?
EVE THREE SHOT Premium does not contain drowsy ingredients. EVE A Tablets, EVE A Tablets EX, EVE Quick, and EVE Quick DX may cause drowsiness, so avoid driving or operating machinery after taking them.

What's the difference between the EVE products?

• EVE A Tablets: Easy to take, suitable for various pain types.
• EVE A Tablets EX: Suitable for severe menstrual pain and headaches.
• EVE Quick, EVE Quick DX: Particularly suitable for headaches, contain stomach-protecting ingredients.
• EVE THREE SHOT Premium: Quickly relieves severe headaches, menstrual pain, and shoulder pain.

Can it be taken during pregnancy or breastfeeding?

It is prohibited within 12 weeks of the expected delivery date. Consult a physician if breastfeeding.

Can it be taken with cold medicine or other drugs?

Do not take it with other medications.

How many tablets should be taken each time?

• EVE A Tablets, EVE A Tablets EX, EVE Quick, and EVE Quick DX: 2 tablets per dose.

• EVE THREE SHOT Premium: 3 tablets per dose.

Will a dent in the packaging affect the product quality?

No, it will not affect the quality. Please use it with confidence.

Will taking ibuprofen worsen COVID-19 infection?
There is currently no scientific evidence that ibuprofen worsens COVID-19 infection.

Can it be taken if you have COVID-19?

Yes, it can be taken according to the dosage and administration instructions. If you experience symptoms such as difficulty breathing, low energy, or high fever, especially if you are elderly or have underlying health conditions, please seek medical attention immediately.

Does EVE contain ibuprofen?

Yes, EVE A Tablets, EVE A Tablets EX, EVE Quick, and EVE Quick DX contain ibuprofen. EVE THREE SHOT Premium contains both ibuprofen and acetaminophen.

Can EVE be taken for fever or pain after receiving the COVID-19 vaccine?

Yes, it can be taken.

Can EVE be taken for fever or pain before receiving the COVID-19 vaccine?

It is advisable to consult a physician beforehand. Preventive use of antipyretic and analgesic drugs is not recommended before experiencing symptoms after vaccination.

Can EVE be taken for fever or pain during home quarantine?

Yes, EVE pain relief medicine can be taken.

Side Effects and Precautions of EVE Pain Relief Medicine

Side Effects of EVE Pain Relief Medicine

Side Effects of Ibuprofen

Main side effects of ibuprofen include gastrointestinal issues, kidney dysfunction, liver dysfunction, aseptic meningitis, and aspirin-induced asthma. Gastrointestinal issues are a key side effect to watch out for with antipyretic and analgesic medicines, and the same holds true for ibuprofen.

Side Effects of Isopropylantipyrine

Isopropylantipyrine may cause drowsiness and drug rashes. Because repetitive intake can lead to dependence, abuse should be avoided.

Beware of Medication Overuse Headache

For those who suffer from migraines or tension-type headaches, frequent use of headache medicines can cause chronic headaches. This is called "medication overuse headache." Antipyretic and analgesic drugs can be categorized into "single-agent" (products containing only analgesic ingredients) and "combination-agent" (products containing analgesic ingredients and other agents like sedatives or caffeine).

Combination-agent analgesic drugs are known to cause medication overuse headaches more easily, possibly due to the dependency on caffeine and sedative ingredients. To prevent medication overuse headaches, it's generally recommended to choose single-agent products for pain and fever relief. If a customer has a "preferred product," it's advisable to continue using that product instead of mixing multiple products, which increases the risk of medication overuse headaches.

Ingredients and Precautions

Ibuprofen

• Prohibited Users:

  • Individuals who have had allergic reactions to this medicine or its ingredients
  • Individuals who have experienced asthma after taking this or other antipyretic analgesics or cold medicines
  • Children under 15 years old
  • Women within 12 weeks of their expected delivery date

• Consult a Doctor:

  • Individuals previously diagnosed with heart disease, kidney disease, liver disease, systemic lupus erythematosus, mixed connective tissue disease
  • Individuals with a history of stomach or duodenal ulcers, ulcerative colitis, Crohn's disease

Isopropylantipyrine

• Prohibited Users:
  • Should not drive or operate machinery after taking
  • Should not consume alcohol before or after taking

Notes

※ Product information in the article may change. For the latest information, please refer to the manufacturer's official website.
※ Prices in the article are for reference only; the actual price and stock status may vary based on the website at the time of purchase.
※ Dosage may vary by age. Please strictly follow the instructions and precautions on the product packaging or the accompanying pamphlet when using.